Novel Chiral Organozinc Species for Use in Organic and Drug Synthesis
RFT-18
Highly enantioselective monomeric and polymeric catalysts have been developed for the asymmetric addition of alkyl groups to aldehydes.
Enantioselective monomeric and polymeric catalysts have been developed for different asymmetric reactions including the alkylation of aldehydes, the epoxidation of olefins, and the reduction of ketones. The resulting chiral products from these processes are important in general organic synthesis as well as in drug synthesis. The polymeric version of these catalysts also has the potential advantage for application in flow reactors for large-scale (continuous flow) drug production. Chiral secondary alcohols can be produced in high optical purity by using this technology. The optically active alcohols generated from this technology can also serve as precursors to other chiral organic compounds. This technology is, therefore, potentially very useful for the production of fine chemicals including chiral drug molecules.