Polymeric Catalysts for Large Scale Drug Production
RFT-18
Highly enantioselective monomeric and polymeric catalysts have been developed for the asymmetric addition of alkyl groups to aldehydes. These catalysts allow the synthesis of various chiral secondary alcohols in excellent optical yields. The chiral alcohols prepared from these processes are important in general organic synthesis as well as in drug synthesis. The polymeric version of these catalysts is particularly useful since it allows easy recycling and reuse of these large-scale (continuous flow) drug production.
Chiral secondary alcohols can be produced in high optical purity by using this technology. The optically active alcohols generated from this technology can also serve as precursors to other chiral organic comounds. This technology is, therefore, potentially very useful for the production of fine chemicals including chiral drug molecules.
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File: rft-18.pdf
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