Novel Method of Releasing Liposomal Drugs by a Cancer-Associated Enzyme
RFT-151
Scientists at NDSU have recently invented a method to release drugs and other molecules from liposomes triggered by an enzyme which is responsible for cancer cell invasion and metastasis.
The uniquely-designed liposomes release the encapsulated contents in the presence of the enzyme matrix metalloproteinase-9 (MMP-9) within an hour. Other MMPs and proteolytic enzymes do not release the contents from the liposomes. The rate and the extent of contents release are easily controlled by the amount of the active enzyme and the lipid formulations of the liposomes.
In addition, inhibitors of MMP-9 can be delivered from the liposomes with a built-in “feedback” regulation.
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File: rft-151.pdf
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Jonathan L. Tolstedt
Licensing Associate/Patent Agent
NDSU Research Foundation
Fargo, North Dakota
(701) 231-8173 Work
(701) 231-6661 Fax
http://www.ndsuresearchfoundation.org/